Increases likelihood of allergic reactions which can distract the immune system. Victims distrust of others makes them unlikely to seek treatment or cooperate with others Irrational delusions and mental symptoms. The loss of fluid through sweating also increases infection rates due to poor hygiene. People in cold climates especially vulnerableįluid discharge through sneezing greatly increases infection rates. Serious fluid build and discharge from the lungs. The expulsion of infected material through projectile vomiting increases the risk of infection Slight chance of bursting which can spread diseaseĭecrease in red blood cells or haemoglobin in the blood can lead to hypoxia in the organs Painful lumps containing pockets of the pathogen. Inability to sleep makes people irritable and less productive The skin becomes blistered and painful, slightly increasing infectivity Slight chance of infection when kissingĬhance of infection by spreading pathogen into surroundings, especially in high density, urban areas Irritated stomach lining leads to discomfort. It costs a total of 779 DNA points to evolve all 32 symptoms (283 with Sympto-Stasis), so it is impossible to evolve all symptoms without Sympto-Stasis, mutations or the Unlimited Strain cheat. To get to Total Organ Failure from Coughing, which is the cheapest way, it will cost 47 DNA points. For example, if you are evolving symptoms that cost 2, 5, 12, and 19, when you get to the symptom that costs 5, it will be six, when you finally get to the symptom that costs 19, it will now be 22. Unless you have enabled the Sympto-Stasis gene, each symptom evolved from the six initially available will have an additional point added.

The below table lists the base symptom costs for each symptom. You will get achievements for every symptom combo you trigger. They are not reversible once they evolve they remain in effect even if you devolve the symptoms that triggered them. Some combos increase research speed while others decrease it. The most infective are Skin Lesions, Necrosis and Dysentery next to Insanity, Systemic Infection, and Diarrhoea tying at 6 infectivity increase.Ĭertain symptoms will create symptom combos, which generally increase disease effectiveness, but also increase awareness of the disease. The most deadly are Total Organ Failure, Hemorrhagic Shock and Necrosis. These initially available symptoms are Nausea, Coughing, Rash, Insomnia, Cysts, and Anaemia. The others must be evolved after you have evolved a symptom in contact with it. In the standard diseases, there are 6 symptoms available immediately. Evolving a symptom costs DNA points, but each evolution will make your pathogen increase infectivity, severity, or lethality. Symptoms can be evolved through the Symptoms screen.

Plague inc evolved symptom combos